01. THEORETICAL FOUNDATION
Defining ABCD.
Adiposity-Based Chronic Disease is a diagnostic term that replaces "obesity" with a focus on metabolic dysfunction rather than body mass index alone.
Ectopic Fat
Deposition
The infiltration of lipid into non-adipose organs (liver, muscle, pancreas) causing cellular stress and lipotoxicity.
Pathogenic Marker: NASH/NAFLD
Endocrine
Dysfunction
Hypertrophic adipocytes secrete pro-inflammatory cytokines (IL-6, TNF-α), driving systemic insulin resistance.
Clinical Metric: CRP levels
Systemic Complications Map
Metabolic Domain